Answer: Paul Erdős, of course! As the Erdős number describes the "collaborative distance" in authorship of mathematical papers between mathematician Paul Erdős and another person it is only natural that Paul Erdős holds this position.
Answer: 3 Of course, as time passes, the smallest Erdős number that can still be achieved will necessarily increase, as mathematicians with low Erdős numbers die and become unavailable for collaboration.
Answer: 5 Portman collaborated (using her birth name, Natalie Hershlag) with Abigail A. Baird, who has a collaboration path (Gazzaniga, Michael S. -> Victor, Jonathan D.) leading to Joseph Gillis, who has an Erdős number of 1.
Answer: 312211 John Conway's "look and say" sequence has no digits other than 1, 2, and 3 in it, unless the seed number contains such a digit or a run of more than three of the same digit. A degenerate sequence appears with the seed of 22.